Dominik Sleziona, M.Sc.

Contents

Abstract

A challenge in the development of new active ingredients is the low water solubility of the new molecules, caused by large molecular weights and lipophilic properties. This also leads to a low bioavailability of these substances. Therefore, a more detailed understanding of the dissolution process of drug molecules is needed.
 

Description

Common approaches to increase the water solubility of active pharmaceutical ingredients are particle size reduction and the embedding into hydrophilic carrier substances to create a solid dispersion. In this study, a cumulative concept of both approaches is used to manufacture a subtype of solid dispersions. The so called solid crystalline suspensions are defined by their crystalline character, which gives better storage stability than i.e. amorphous dispersions. In this study, a manufacturing method to prepare and disperse submicron crystalline drug particles into a crystalline carrier matrix is developed.

To investigate the dissolution behavior of the resulting product, a finite volume simulation, based on the phase field approach, is used. This model gives the ability to consider different particle shapes, anisotropy and to track the effects of phase transition and diffusion separately.

Curriculum Vitae