Dr. Ramona Strob

Contents

Abstract

One of the major problems for the development of new drug substances is the poor aqueous solubility. The preparation of submicron sized particles (0.1-1µm) can increase the dissolution rate as well as the solubility of the drugs, thus increases their bioavailability. In this work spray drying is used for the generation of submicron sized particles.
 

Description

Spray Drying is as a gentle, continuous and single-step technique, widely used in the pharmaceutical application, which converts a fluid into a dry powder.

Nevertheless, the production of particles at the submicrometer range using conventional spray dryers is limited due to the low collection efficiency (< 2 µm) of cyclone separator, the low yield and due to insufficient forces of atomization to produce small droplets.[1]

The aim of this research is the production of submicron particles using spray drying technique. Therefore the identification of a new robust atomization technique generating small droplet sizes and a narrow droplet size distribution is from common interest.
 

References

1. Sosnik, A., Seremeta, K., Adv. Colloid. Interface Sci. , 223, 40-54, 2015

Curriculum Vitae