Doctoral Defense René Brands

In his PhD, René focused on real-time release testing (RTRT) in tablet manufacturing, developing and applying process analytical technologies (PAT) for in-line monitoring of critical quality attributes (CQAs) such as drug content, porosity, hardness and disintegration time. The data collected from these sensors were used to optimize lubrication strategies, linking a deeper mechanistic understanding of the tableting process to improved product quality and process robustness.
Building on this foundation, René also extended his approach to the coating process, where he implemented RTRT for coating end-point detection using an innovative complemental hard modeling approach.
This work demonstrated a mechanistic and reliable method to assess tablet quality, further highlighting the potential of PAT and RTRT for enhancing pharmaceutical manufacturing processes.
René is continuing his professional journey as Senior Formulation Scientist & Project Manager at NextPharma in Waltrop. We wish him all the best for the future.