Books

Multiparticulate Drug Delivery: Formulation, Processing and Manufacturing

Innovative Arzneiformen: Ein Lehrbuch für Studium und Praxis

Die Tablette: Handbuch der Entwicklung, Herstellung und Qualitätssicherung

2024

• Mansuri, Ali and Vora, Paras and Feuerbach, Tim and Winck, Judith and Vermeer, A. W. P. and Hoheisel, Werner and Kierfeld, Jan and Thommes, Markus
  A Monte Carlo simulation of tracer diffusion in amorphous polymers
  (2024) Journal of Soft Matter, 20, pp. 6204-6214
  http://dx.doi.org/10.1039/D4SM00782D
   
• da Igreja, Philip, Tim Grenda, Jens Bartsch, and Markus Thommes
  Design and Characterization of a Continuous Melt Milling Process Tailoring Submicron Drug Particles
  (2024) Processes, 12(7)
  https://doi.org/10.3390/pr12071417
   
• Düphans, Vanessa, Vincent Kimmel, Lukas Messing, Gerhard Schaldach, and Markus Thommes
  Experimental and numerical characterization of screw elements used in twin-screw extrusion
  (2024) Pharmaceutical Development and Technology, 29(7), 675–683.
  https://doi.org/10.1080/10837450.2024.2378323
   
• K. Hoppe, F. Giesa, G. Schaldach, M. Thommes, D. Pieloth,
  Optimization of filter structures by evolutionary strategies,
  (2024) Materials Today Communications, 38
  https://doi.org/10.1016/j.mtcomm.2024.108510
   

• Amelie M Mattusch, Gerhard Schaldach, Jens Bartsch, Markus Thommes
  Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method
  (2024) Pharmaceutical Development and Technology, 29(4), pp. 281–290
  https://doi.org/10.1080/10837450.2024.2329115

• Justen, Anna, Gerhard Schaldach, and Markus Thommes
  Insights into the Mechanism of Enhanced Dissolution in Solid Crystalline Formulations
  (2024) Pharmaceutics, 16(4)
  https://doi.org/10.3390/pharmaceutics16040510
   
• Kimmel, Vincent, Enrico Ercolin, Robin Zimmer, Muhammet Yörük, Judith Winck, and Markus Thommes
  Measuring and Modeling of Melt Viscosity for Drug Polymer Mixtures
  (2024) Pharmaceutics, 16(3)
  https://doi.org/10.3390/pharmaceutics16030301
   
• René Brands, Christopher Mathias, Jens Bartsch, Markus Thommes,
  Advancing tablet lubrication: A systematic comparison of feed frame lubrication and internal lubrication,
  (2024) Powder Technology, 434
  https://doi.org/10.1016/j.powtec.2024.119369
   
• Justen, Anna, Alina Faye Weltersbach, Gerhard Schaldach, and Markus Thommes
  Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations
  (2024) Processes, 12(1)
  https://doi.org/10.3390/pr12010100
   

2023

• Clara Lauscher,  Alexander Licau,  Gerhard Schaldach, Markus Thommes
  Characterization of Sprays Generated by the Expansion of Emulsions with Liquid Carbon Dioxide
  (2023) Chemical Engineering and Technology, 47, pp. 262–267
  https://doi.org/10.1002/ceat.202300261
   
• René Brands, Noah Tebart, Markus Thommes
  UV/Vis spectroscopy as an in-line monitoring tool for tablet content uniformity
  (2023) Journal of Pharmaceutical and Biomedical Analysis, 236
  https://doi.org/10.1016/j.jpba.2023.115721
   
• Klueppelberg, Jana, Ulrich A. Handge, Markus Thommes, and Judith Winck
  Composition Dependency of the Flory–Huggins Interaction Parameter in Drug–Polymer Phase Behavior.
  (2023) Pharmaceutics, 15(12):2650
  https://doi.org/10.3390/pharmaceutics15122650
   
• Ali Mansuri, Milan Völkel, Dilshan Mihiranga, Tim Feuerbach, Judith Winck, Arnoldus W. P. Vermeer, Werner Hoheisel, Markus Thommes
  Predicting self-diffusion coefficients in semi-crystalline and amorphous solid dispersions using free volume theory
  (2023) European Journal of Pharmaceutics and Biopharmaceutica, 190, pp. 107-120
  https://doi.org/10.1016/j.ejpb.2023.07.001
   
• Daniel Nesges, Tom Lang, Thomas Birr, Markus Thommes, Jens Bartsch
  Planetary roller melt granulation (PRMG) – A new continuous method for powder processing
  (2023) Powder Technology, 427
  https://doi.org/10.1016/j.powtec.2023.118728
   
• Tom Lang, Andreas Bramböck, Markus Thommes, Jens Bartsch
  Material Transport Characteristics in Planetary Roller Melt Granulation
  (2023) Pharmaceutics, 15(8)
  https://doi.org/10.3390/pharmaceutics15082039
   
• Judith Winck, Tobias Gottschalk, Markus Thommes
  Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion
  (2023) Pharmaceutics 15(5)
  https://doi.org/10.3390/pharmaceutics15051417
   
• Ali Mansuri, Milan Völkel, Tim Feuerbach, Judith Winck, Arnoldus W. P. Vermeer, Werner Hoheisel, Markus Thommes
  Modified Free Volume Theory for Self-Diffusion of Small Molecules in Amorphous Polymers
  (2023) Macromolecules, 56(8), pp. 3224-3237
  https://doi.org/10.1021/acs.macromol.2c02451
   
• Ali Mansuri, Philipp Münzner, Anrika Heermant, Sebastian Hänsch, Tim Feuerbach, Björn Fischer, Judith Winck, Arnoldus W.P. Vermeer, Werner Hoheisel, Roland Böhmer, Catalin Gainaru, Markus Thommes
  Characterizing Phase Separation of Amorphous Solid Dispersions Containing Imidacloprid
  (2023) Moldecular Pharmaceutics, 20(4), pp. 2080-2093
  https://doi.org/10.1021/acs.molpharmaceut.2c01043
   
• Ali Mansuri, Philipp Münzner, Anrika Heermant, Fabian Patzina, Tim Feuerbach, Judith Winck, Arnoldus W. P. Vermeer, Werner Hoheisel, Roland Böhmer, Catalin Gainaru, Markus Thommes
  Molecular Dynamics and Diffusion in Amorphous Solid Dispersions Containing Imidacloprid
  (2023) Molecular Pharmaceutics, 20(4), pp. 2067-2079
  https://doi.org/10.1021/acs.molpharmaceut.2c01042
   
• Anna Justen, Christopher Kurth, Gerhard Schaldach, Markus Thommes
  Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation
  (2023) Chemical Engineering and Technology, 46(2), pp. 343–349
  https://doi.org/10.1002/ceat.202200357
   
• Hoppe, Kevin, Lukas Wischemann, Gerhard Schaldach, Reiner Zielke, Wolfgang Tillmann, Markus Thommes, and Damian Pieloth
  Filtration Kinetics of Depth Filters—Modeling and Comparison with Tomographic Data of Particle Depositions
  (2023) Atmosphere, 14(4)
  https://doi.org/10.3390/atmos14040640
   

• Damian Pieloth, Matthias Rodeck, Gerhard Schaldach, Markus Thommes
  Categorization of Sprays by Image Analysis with Convolutional Neuronal Networks
  (2023) Chemical Engineering and Technology, 46(2), pp. 264–269
  https://doi.org/10.1002/ceat.202200356

• Maren Zimmermann, Felix Michel, Jens Bartsch, Markus Thommes
  A novel approach of external lubrication in a rotary tablet press using electrostatics
  (2023) Drug Development and Industrial Pharmacy, 48, pp. 737-744
  https://doi.org/10.1080/03639045.2023.2165662
   

2022

• Dominik Sleziona, David R. Ely, Markus Thommes
  Modeling of Particle Dissolution Behavior Using a Geometrical Phase-Field Approach
  (2022) Molecular Pharmaceutics, 19(11), pp. 3749–3756
  https://doi.org/10.1021/acs.molpharmaceut.2c00214
   
• Tobias Gottschalk, Cihangir Özbay, Tim Feuerbach, Markus Thommes
  Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion
  (2022) Pharmaceutics, 14(9), 1757
  https://doi.org/10.3390/pharmaceutics14091757
   
• Clara Lauscher, Gerhard Schaldach, Markus Thommes
  Particle Generation with Liquid Carbon Dioxide Emulsions
  (2022) Chemical Engineering and Technology, 45(9), pp. 1631–1636
  https://doi.org/10.1002/ceat.202200176


• Maria Evers, Dominik Weis, Sergiy Antonyuk, Markus Thommes
  Particle movement in the spheronizer – Experimental investigations with respect to the toroidal and poloidal direction
  (2022) Powder Technology, 404, 117452
  https://doi.org/10.1016/j.powtec.2022.117452
   
• Maren Zimmermann, Carola Raffel, Jens Bartsch, Markus Thommes
  Simulation of Powder Flow Behavior in an Artificial Feed Frame Using an Euler-Euler Model
  (2022) Chemical Engineering and Technology, 45(5), pp. 853–859
  https://doi.org/10.1002/ceat.202100580
   
• Friederike Wolbert, Ineke-Katharina Fahrig, Tobias Gottschalk, Christian Luebbert, Markus Thommes, Gabriele Sadowski
  Factors Influencing the Crystallization-Onset Time of Metastable ASDs
  (2022) Pharmaceutics, 14(2), 269
  https://doi.org/10.3390/pharmaceutics14020269
   
• Clara Lauscher, Gerhard Schaldach, Markus Thommes
  An Approach for Small Droplet Production: Nebulization by Expansion of Water/Liquid Carbon Dioxide Emulsion
  (2022) Atomization and Sprays, 32(4), pp. 77–93
  https://doi.org/10.1615/AtomizSpr.2022039582
   
• Tobias Gottschalk, B. Grönniger, E. Ludwig, F.  Wolbert, Tim Feuerbach, Gabriele Sadowski, Markus Thommes
  Influence of process temperature and residence time on the manufacturing of amorphous solid dispersions in hot melt extrusion
  (2022) Pharmaceutical Development and Technology, 27(3), pp. 313–318
  https://doi.org/10.1080/10837450.2022.2051549 

   

2021

• Ali Mansuri, Philipp Münzner, Tim Feuerbach, A.W.P. Vermeer, Werner Hoheisel, Roland Böhmer, Markus Thommes, Catalin Gainaru
  The relaxation behavior of supercooled and glassy imidacloprid
  (2021) Journal of Chemical Physics, 155(17), 174502
  https://doi.org/10.1063/5.0067404
   
• Maria Evers, Amelie Mattusch, Dominik Weis, Edwin García, Sergiy Antonyuk, Markus Thommes
  Elucidation of mass transfer mechanisms in pellet formation by spheronization
  European Journal of Pharmaceutics and (2021) Biopharmaceutics, 160, pp. 92–99
  https://doi.org/10.1016/j.ejpb.2021.01.013
   
• Karsten Flügel, Katharina Schmidt, Lena Mareczek, Michael Gäbe, Robert Hennig, Markus Thommes.
  Impact of incorporated drugs on material properties of amorphous solid dispersions
  (2021) European Journal of Pharmaceutics and Biopharmaceutics, 159, pp. 88-98
  https://doi.org/10.1016/j.ejpb.2020.12.017
   
• Tim Feuerbach, Markus Thommes
  Design and characterization of a screw extrusion hot-end for fused deposition modeling
  (2021) Molecules, 26(3), 590
  https://doi.org/10.3390%2Fmolecules26030590
   
• Dominik Weis, Philipp Grohn, Maria Evers, Markus Thommes, Edwin García, Sergiy Antonyuk.
  Implementation of formation mechanisms in DEM simulation of the spheronization process of pharmaceutical pellets
  (2021) Powder Technology, 378, Part A, pp. 667-679 
  https://doi.org/10.1016/j.powtec.2020.09.013
   
• Maren Zimmermann, Markus Thommes
  Residence time and mixing capacity of a rotary tablet press feed frame
  (2021) Drug Development and Industrial Pharmacy, 47(5), pp. 790–798
  https://doi.org/10.1080/03639045.2021.1934871
   
• Philip da Igreja, Annika Erve, Markus Thommes.
  Melt milling as manufacturing method for solid crystalline suspensions
  (2021) European Journal of Pharmaceutics and Biopharmaceutics, 158, pp. 245-253
  https://doi.org/10.1016/j.ejpb.2020.11.020
   
• Dominik Sleziona, Amelie Mattusch, Gerhard Schaldach, David R. Ely, Gabriele Sadowski, Markus Thommes
  Determination of inherent dissolution performance of drug substances
  (2021) Pharmaceutics, 2021, 13(2), pp. 1–12, 146
  https://doi.org/10.3390/pharmaceutics13020146
   

2020

• Raj Schneider, Jana Kerkhoff, Andreas Danzer, Amelie Mattusch, Andrijan Ohmann, Markus Thommes, Gabriele Sadowski
  The interplay of dissolution, solution crystallization and solid-state transformation of amorphous indomethacin in aqueous solution
  (2020) International Journal of Pharmaceutics: X, 2, 100063
  https://doi.org/10.1016/j.ijpx.2020.100063
   
• Karsten Flügel, Robert Hennig, Markus Thommes.
  Impact of structural relaxation on mechanical properties of amorphous polymers
  (2020) European Journal of Pharmaceutics and Biopharmaceutics, 154, pp. 214-221
  https://doi.org/10.1016/j.ejpb.2020.07.016
   
• Ramona Strob, Tejas Babaria, Matthias Rodeck, Gerhard Schaldach, Peter Walzel, Markus Thommes
  Evaluation of spray impact on a sphere with a two-fluid nozzle
  (2020) Journal of Aerosol Science, 140, 105483
  https://doi.org/10.1016/j.jaerosci.2019.105483
   
• Tim Feuerbach, Stefanie Kock, Markus Thommes
  Slicing parameter optimization for 3D printing of biodegradable drug-eluting tracheal stents
  (2020) Pharmaceutical Development and Technology, 25(6), pp. 650–658
  https://doi.org/10.1080/10837450.2020.1727921
   
• Philipp Grohn, Dominik Weis, Markus Thommes, Stefan Heinrich, Sergiy Antonyuk
  Contact Behavior of Microcrystalline Cellulose Pellets Depending on their Water Content
  (2020) Chemical Engineering and Technology, 43(5), pp. 887–895
  https://doi.org/10.1002/ceat.201900517 
   
• Kevin Hoppe, Michail Maricanov, Gerhard Schaldach, Reiner Zielke, Dirk Renschen, Wolfgang Tillmann, Markus Thommes, Damian Pieloth
  Modeling the separation performance of depth filter considering tomographic data
  (2020) Environmental Progress and Sustainable Energy, 39(5), (Article in Press)
  https://doi.org/10.1002/ep.13423
   

2019

• Karsten Flügel, Robert Hennig, Markus Thommes
  Determination of the Structural Relaxation Enthalpy Using a Mathematical Approach
  (2019) Journal of Pharmaceutical Sciences, 108(11), pp. 3675–3683
  https://doi.org/10.1016/j.xphs.2019.08.013
   
• Dominik Weis, Fabian Krull, Julia Mathy, Maria Evers, Markus Thommes, Sergiy Antonyuk
  A contact model for the deformation behaviour of pharmaceutical pellets under cyclic loading
  (2019) Advanced Powder Technology,  30(11), pp. 2492–2502
  https://doi.org/10.1016/j.apt.2019.07.026
   
• Maria Evers, Dominik Weis, Sergiy Antonyuk, Markus Thommes
  Scale-up of the rounding process in pelletization by extrusion-spheronization
  (2019) Pharmaceutical Development and Technology, 24(8), pp. 1014–1020
  https://doi.org/10.1080/10837450.2019.1621900
   
• Jens Wesholowski, Kevin Hoppe, Kathrin Nickel, Christian Muehlenfeld, Markus Thommes
  Scale-Up of pharmaceutical Hot-Melt-Extrusion: Process optimization and transfer
  (2019) European Journal of Pharmaceutics and Biopharmaceutics, 142, pp. 396–404
  https://doi.org/10.1016/j.ejpb.2019.07.009
   
• Adrian Dobrowolski, Ramona Strob, Jan Felix Dräger-Gillessen, Damian Pieloth, Gerhard Schaldach, Helmut Wiggers, Markus Thommes
  Preparation of submicron drug particles via spray drying from organic solvents
  (2019) International Journal of Pharmaceutics, 567, 118501
  https://doi.org/10.1016/j.ijpharm.2019.118501
   
• Adrian Dobrowolski, Damian Pieloth, Helmut Wiggers, Markus Thommes
  Electrostatic precipitation of submicron particles in a molten carrier
  (2019) Pharmaceutics, 11(6), 276
  https://doi.org/10.3390%2Fpharmaceutics11060276

• Tim Feuerbach, Sara Callau-Mendoza, Markus Thommes
  Development of filaments for fused deposition modeling 3D printing with medical grade poly(lactic-co-glycolic acid) copolymers
  (2019) Pharmaceutical Development and Technology, 24(4), pp. 487–493
  https://doi.org/10.1080/10837450.2018.1514522
   
• Jens Wesholowski, Helmut Podhaisky, Markus Thommes
  Comparison of residence time models for pharmaceutical twin-screw-extrusion processes
  (2019) Powder Technology, 341, pp. 85–93
  https://doi.org/10.1016/j.powtec.2018.02.054
   

2018

• Dominik Weis, Maria Evers, Markus Thommes, Sergiy Antonyuk
  DEM simulation of the mixing behavior in a spheronization process
  (2018) Chemical Engineering Science, 192, pp. 803–815
  https://doi.org/10.1016/j.ces.2018.07.057
   
• Jens Wesholowski, Sebastian Prill, Andreas Berghaus, Markus Thommes
  Inline UV/Vis spectroscopy as PAT tool for hot-melt extrusion
  Drug Delivery and Translational Research, 2018, 8(6), pp. 1595–1603
  https://doi.org/10.1007/s13346-017-0465-5


•  Jens Wesholowski, Andreas Berghaus, Markus Thommes
  Investigations concerning the residence time distribution of twin-screw-extrusion processes as indicator for inherent mixing
  (2018) Pharmaceutics, 10(4), art. no. 207
  https://doi.org/10.3390/pharmaceutics10040207
   
• Ramona Strob, Adrian Dobrowolski, Damian Pieloth, Gerhard Schaldach, Helmut Wiggers, Peter Walzel, Markus Thommes
  Preparation and characterization of spray-dried submicron particles for pharmaceutical application
  (2018) Advanced Powder Technology, 29(12), pp. 2920–2927
  https://doi.org/10.1016/j.apt.2018.09.016
   
• Tim Feuerbach, Stefanie Kock, Markus Thommes
  Characterisation of fused deposition modeling 3D printers for pharmaceutical and medical applications
  (2018) Pharmaceutical Development and Technology, 23(10), pp. 1136–1145
  https://doi.org/10.1080/10837450.2018.1492618
   
• Łukasz Pałkowski, Maciej Karolak, Bartłomiej Kubiak, Jerzy Błaszczyński, Roman Słowińskicd, Markus Thommes, Peter Kleinebudde, Jerzy Krysiński
  Optimization of pellets manufacturing process using rough set theory
  (2018) European Journal of Pharmaceutical Sciences, 124, pp. 295–303
  https://doi.org/10.1016/j.ejps.2018.08.027
   
• Ramona Strob, Adrian Dobrowolski, Gerhard Schaldach, Peter Walzel, Markus Thommes
  Preparation of spray dried submicron particles: Part A – Particle generation by aerosol conditioning
  (2018) International Journal of Pharmaceutics, 548(1), pp. 423–430
  https://doi.org/10.1016/j.ijpharm.2018.06.067
   
• Adrian Dobrowolski, Ramona Strob, Jessica Nietfeld, Damian Pieloth, Helmut Wiggers, Markus Thommes
  Preparation of spray dried submicron particles: Part B – Particle recovery by electrostatic precipitation
  (2018) International Journal of Pharmaceutics, 548(1), pp. 237–243
  https://doi.org/10.1016/j.ijpharm.2018.06.069
   
• Jens Wesholowski, Andreas Berghaus, Markus Thommes
  Inline determination of residence time distribution in hot-melt-extrusion
  (2018) Pharmaceutics, 10(2), art. no. 49
  https://doi.org/10.3390/pharmaceutics10020049
   
• Jens Kamplade, Ivette Hohlfeld, Marcus Kelz, Markus Thommes, Peter Walzel
  Effect of Coandǎ-deflection-openings on the spray behavior of pressure swirl nozzles
  (2018) Atomization and Sprays, 28 (3), pp. 281-297.
  http://dx.doi.org/10.1615/AtomizSpr.2018025126
   

2017

• Dominik Weis, Maria Niesing, Markus Thommes, Sergiy
  Corrigendum to: Partikelkinematik in der Sphäronisation pharmazeutischer Pellets
  (2017) Chemie Ingenieur Technik, 89, 9, (1107)
   
• Dominik Weis, Maria Niesing, Markus Thommes, Sergiy Antonyuk
  Particle Kinematics in Spheronization of Pharmaceutical Pellets | Partikelkinematik in der Sphäronisation pharmazeutischer Pellets
  (2017) Chemie-Ingenieur-Technik, 89(8), pp. 1083–1091
  https://doi.org/10.1002/cite.201600154
   
• Dominik Weis, Maria Niesing, Markus Thommes, Sergiy Antonyuk
  Effect of the particle shape on the particle dynamics in a spheronization process
  (2017) EPJ Web of Conferences, 140, art. no. 15005, .
  https://doi.org/10.1051/epjconf/201714015005
   
• Diána Hegyesi, Markus Thommes, Peter Kleinebudde, Tamás Sovány, Péter Kása Jr, András Kelemen, Klára Pintye-Hódi,  Géza Regdon Jr
  Preparation and physicochemical characterization of matrix pellets containing APIs with different solubility via extrusion process
  (2017) Drug Development and Industrial Pharmacy, 43(3), pp. 458–464
  https://doi.org/10.1080/03639045.2016.1261150
   

2016

• Robin Meier, Markus Thommes, Norbert Rasenack, Kalus-Peter Moll, Markus Krumme, Peter Kleinebudde
  Granule size distributions after twin-screw granulation – Do not forget the feeding systems
  (2016) European Journal of Pharmaceutics and Biopharmaceutics, 106, pp. 59–69
  https://doi.org/10.1016/j.ejpb.2016.05.011
   
• Eva Julia Laukamp, Klaus Knop, Markus Thommes, Jörg Breitkreutz
  Micropellet-loaded rods with dose-independent sustained release properties for individual dosing via the Solid Dosage Pen
  (2016) International Journal of Pharmaceutics, 499(1-2), pp. 271–279
  https://doi.org/10.1016/j.ijpharm.2016.01.001
   
• Dominik Weis, Markus Thommes, Sergiy Antonyuk
  Untersuchung des Durchmischungsverhaltens im Sphäroniser mittels DEM-Simulationen
  (2016) Chemie-Ingenieur-Technik, 88 (9), pp. 1360-1361. 
  https://doi.org/10.1002/cite.201650323
   

2015

• Robin Meier, Markus Thommes, Norbert Rasenack, Markus Krumme, Kalus Peter Moll, Peter Kleinebudde
  Simplified formulations with high drug loads for continuous twin-screw granulation
  (2015) International Journal of Pharmaceutics, 496(1), pp. 12–23
  https://doi.org/10.1016/j.ijpharm.2015.05.060
   
• Joanna Ronowicz, Markus Thommes, Peter Kleinebudde, Jerzy Krysiński
  A data mining approach to optimize pellets manufacturing process based on a decision tree algorithm
  (2015) European Journal of Pharmaceutical Sciences, 73, pp. 44–48
  https://doi.org/10.1016/j.ejps.2015.03.013
   
• Florian E. Kiene, Miriam Pein, Markus Thommes
  Orientation to determine quality attributes of flavoring excipients containing volatile molecules
  (2015) Journal of Pharmaceutical and Biomedical Analysis, 2015, 110, pp. 20–26
  https://doi.org/10.1016/j.jpba.2015.01.033
   
• Markus W. Tackenberg, Carola Geisthövel, Andreas Marmann, Heike P. Schuchmann, Peter Kleinebudde, Markus Thommes
  Mechanistic study of carvacrol processing and stabilization as glassy solid solution and microcapsule
  (2015) International Journal of Pharmaceutics, 2015, 478(2), pp. 597–605
  https://doi.org/10.1016/j.ijpharm.2014.12.012
   
• Gustavo Freire Petrovick, Miriam Pein, Markus Thommes, Jörg Breitkreutz
  Spheronization of solid lipid extrudates: A novel approach on controlling critical process parameters
  (2015) European Journal of Pharmaceutics and Biopharmaceutics, 2015, 92, pp. 15–21
  https://doi.org/10.1016/j.ejpb.2015.02.004
   
• Eva Julia Laukamp, An-Katrien Vynckier, Jody Voorspoels, Markus Thommes, Jörg Breitkreutz
  Development of sustained and dual drug release co-extrusion formulations for individual dosing
  (2015) European Journal of Pharmaceutics and Biopharmaceutics, 89, pp. 357–364
  https://doi.org/10.1016/j.ejpb.2014.12.027
   
• Markus W. Tackenberg, Ralph Krauss, Andreas Marmann, Markus Thommes, Heike P. Schuchmann, Peter Kleinebudde
  Encapsulation of liquids using a counter rotating twin screw extruder
  (2015) European Journal of Pharmaceutics and Biopharmaceutics, 89, pp. 9–17
  https://doi.org/10.1016/j.ejpb.2014.11.017
   

2014

• Martin Koester, R. Edwin García, Markus Thommes
  Spheronization process particle kinematics determined by discrete element simulations and particle image velocimentry measurements
  (2014) International Journal of Pharmaceutics, 477(1), pp. 81–87
  https://doi.org/10.1016/j.ijpharm.2014.10.007
   
• Christian Muehlenfeld, Markus Thommes
  Small-scale twin-screw extrusion - evaluation of continuous split feeding
  (2014) The Journal of pharmacy and pharmacology, 66(12), pp. 1667–1676
  https://doi.org/10.1111/jphp.12301
   
• Eva Julia Laukamp, Markus Thommes, Jörg Breitkreutz
  Hot-melt extruded drug-loaded rods: Evaluation of the mechanical properties for individual dosing via the Solid Dosage Pen
  (2014) International Journal of Pharmaceutics, 475(1), pp. 344–350
  https://doi.org/10.1016/j.ijpharm.2014.09.001
   
• Markus W. Tackenberg, Markus Thommes, Heike P. Schuchmann, Peter Kleinebudde
  Solid State of Processed Carbohydrate Matrices from Maltodextrin and Sucrose
  (2014) Journal of Food Engineering, 129, pp. 30–37
  https://doi.org/10.1016/j.jfoodeng.2014.01.003
   
• David R. Ely, R. Edwin García, Markus Thommes
  Ostwald-Freundlich Diffusion-Limited Dissolution Kinetics of Nanoparticles
  (2014) Powder Technology, 257, pp. 120–123
  https://doi.org/10.1016/j.powtec.2014.01.095
   
• Cornelia Krueger, Markus Thommes, Peter Kleinebudde
  Influence of storage condition on properties of MCC II-based pellets with theophylline-monohydrate
  (2014) European Journal of Pharmaceutics and Biopharmaceutics, 88(2), pp. 483–491
  https://doi.org/10.1016/j.ejpb.2014.06.006
   
• Elena Reitz, D. Djuric, K. Kolter, Markus Thommes
  Tablet Formulation Containing Solid Dispersions from Soluplus®
  (2014) Pharmazeutische Industrie, 76(2), pp. 286–296
   
• Markus W. Tackenberg, Andreas Marmann, Markus Thommes, Heike P. Schuchmann, Peter Kleinebudde
  Orange terpenes, carvacrol and α-tocopherol encapsulated in maltodextrin and sucrose matrices via batch mixing
  Journal of Food Engineering, 2014, 135, pp. 44–52
  https://doi.org/10.1016/j.jfoodeng.2014.03.010
   

2013

• Elena Reitz, Chris Vervaet, Reinhard H. H. Neubert, Markus Thommes
  Solid crystal suspensions containing griseofulvin-Preparation and bioavailability testing
  (2013) European Journal of Pharmaceutics and Biopharmaceutics, 2013, 83(2), pp. 193–202
  https://doi.org/10.1016/j.ejpb.2012.09.012
   
• Christian Mühlenfeld, Birthe Kann, Maike Windbergs, Markus Thommes
  Solid Dispersions Prepared by Continuous Cogrinding in an Air Jet Mill
  (2013) Journal of Pharmaceutical Sciences, 102(11), pp. 4132–4139
  https://doi.org/10.1002/jps.23731
   
• Cornelia Krueger, Markus Thommes, Peter Kleinebudde
  Influence of MCC II Fraction and Storage Conditions on Pellet Properties
  (2013) European Journal of Pharmaceutics and Biopharmaceutics, 85(3 PART B), pp. 1039–1045
  https://doi.org/10.1016/j.ejpb.2013.07.001
   
• M. Haupt, Markus Thommes, A. Heidenreich, Jörg Breitkreutz
  Lipid-based Intravesical Drug Delivery Systems with Controlled Release of Trospium Chloride for the Urinary Bladder
  (2013) Journal of Controlled Release, 170(2), pp. 161–166
  https://doi.org/10.1016/j.jconrel.2013.05.018
   
• Elena Reitz, Helmut Podhaisky, David Ely, Markus Thommes
  Residence Time Modeling of Hot Melt Extrusion Processes
  (2013) European Journal of Pharmaceutics and Biopharmaceutics, 85(3B), pp. 1200–1205
  https://doi.org/10.1016/j.ejpb.2013.07.019
   
• Susann Just, Frank Sievert, Markus Thommes, Jörg Breitkreutz
  Improved Group Contribution Parameter Set for the Application of Solubility Parameters to Melt Extrusion
  (2013) European Journal of Pharmaceutics and Biopharmaceutics, 85(3B), pp. 1191–1199
  https://doi.org/10.1016/j.ejpb.2013.04.006
   
• Toshiro Sakai , Markus Thommes
  Investigation into mixing capability and solid dispersion preparation using the DSM Xplore Pharma Micro Extruder
  (2014) Journal of Pharmacy and Pharmacology, 66(2), pp. 218–231
  https://doi.org/10.1111/jphp.12085
   
• Marie Guhmann, Markus Thommes, Frédéric Gerber, Norbert Pöllinger, Sandra Klein, Jörg Breitkreutz, Werner Weitschies
  Design of Biorelevant Test Setups for the Prediction of Diclofenac in vivo Features after Oral Administration
  (2013) Pharmaceutical Research, 30(6), pp. 1483–1501
  https://doi.org/10.1007/s11095-013-0974-y
   
• Martin Koester, Markus Thommes
  Analysis of Particle Kinematics in Spheronization via Particle Image Velocimetry
  (2013) European Journal of Pharmaceutics and Biopharmaceutics, 83(2), pp. 307–314
  https://doi.org/10.1016/j.ejpb.2012.08.013
   
• Cornelia Krueger, Markus Thommes
  Multiple Batch Manufacturing of Theophylline Pellets using the Wet-Extrusion/Spheronization Process with κ-Karrageenan as Pelletisation Aid
  (2013) Pharmaceutical Development and Technology, 18(1), pp. 225–235
  https://doi.org/10.3109/10837450.2012.700935
   
• E. Reitz, C. Vervaet, R.H.H. Neubert and M. Thommes
  Grinding in Hot Melt Extrusion – Manufacturing of Solid Crystal Suspensions
  (2013) European Journal of Pharmaceutics and Biopharmaceutics, 83 (2): p. 193-202.
   
• Cornelia Krueger, Markus Thommes, Peter Kleinebudde
  Spheronisation mechanism of MCC II-based pellets
  (2013) Powder Technology, 238, pp. 176–187
  https://doi.org/10.1016/j.powtec.2011.12.052
   

2012

• Martin Köster, Markus Thommes
  Quantification of Mass Transfer During Spheronisation
  AAPS PharmSciTech, 2012, 13(2), pp. 493–497
  https://doi.org/10.1208/s12249-012-9770-y
   
• Christian Mühlenfeld, Markus Thommes
  Miniaturization in Pharmaceutical Extrusion Technology: Feeding as a Challenge of Downscaling
  AAPS PharmSciTech, 2012, 13(1), pp. 94–100
  https://doi.org/10.1208/s12249-011-9726-7
   
• Markus Thommes
  Pharmaceutical Extrusion Technology - Status Quo
  APV Drug Delivery Focus Group Newsletter, 2012
   
• Martin Koester, Emilie Willemsen, Cornelia Krüger, Markus Thommes
  Systematic evaluations regarding interparticular mass transfer in spheronization
  (2012) International Journal of Pharmaceutics, 431(1-2), pp. 84–89
  https://doi.org/10.1016/j.ijpharm.2012.04.045
   
• Klaus Wening, Eva Julia Laukamp, Markus Thommes, Jörg Breitkreutz
  Individual Oral Therapy with Immediate Release and Effervescent Formulations Delivered by the Solid Dosage Pen
  (2012) Journal of Personalized Medicine, 2(4), pp. 217–231
  https://doi.org/10.3390/jpm2040217
   

2011

• Markus Thommes, David R. Ely, M. Teresa Carvjal, Pinal, R.
  Improvement of the Dissolution Rate of Poorly Soluble Drugs by Solid Crystal Suspensions
  (2011) Molecular Pharmaceutics, 8(3), pp. 727–735
  https://doi.org/10.1021/mp1003493
   

2010

• Martin Köster, Markus Thommes
  New Insights into the Pelletization Mechanism by Extrusion/Spheronization
  (2010) AAPS PharmSciTech, 11(4), pp. 1549–1551
  https://doi.org/10.1208%2Fs12249-010-9532-7
   
• Martin Köster, Markus Thommes
  In-line Dynamic Torque Measurement in Twin-Screw Extrusion Process
  (2010) Chemical Engineering Journal, 164(2-3), pp. 371–375
  https://doi.org/10.1016/j.cej.2010.03.076
   
• Cornelia Krüger, Markus Thommes, Peter Kleinebudde
  MCC SANAQ® burst - A new Type of Cellulose and its Suitability to Prepare Fast Disintegrating Pellets
  (2010) Journal of Pharmaceutical Innovation, 5(1-2), pp. 45–57
  http://dx.doi.org/10.1007/s12247-010-9080-4
   
• Aleksander Mendyk, Peter Kleinebudde, Markus Thommes, Angelina Yoo, Jakub Szlęk, Renata Jachowicz
  Analysis of Pellet Properties with use of Artificial Neural Networks
  (2010) European Journal of Pharmaceutical Sciences, 41(3-4), pp. 421–429
  https://doi.org/10.1016/j.ejps.2010.07.010
   
• Markus Thommes, Lieven Baert, Jan Rosier
  800 mg Darunavir Tablets Prepared by Hot Melt Extrusion
  (2010) Pharmaceutical Development and Technology, 16(6), pp. 645–650
  https://doi.org/10.3109/10837450.2010.508077
   

2009

• M. Thommes, R. Pinal, M. T. Carvajal
  Solid Formulations of Crystalline Compounds
  Patent WO/2009/052391
   
• M. Thommes and P. Kleinebudde, Pellets. Eds. K. Mäder und U. Weidenauer,
  Innovative Arzneiformen
  (2009) Wissenschaftliche Verlagsgesellschaft Stuttgart
   
• Julia Krause, Markus Thommes, Jörg Breitkreutz
  Immediate Release Pellets with Lipid Binders Obtained by Solvent-Free Cold Extrusion
  (2009) European Journal of Pharmaceutics and Biopharmaceutics, 71(1), pp. 138–144
  https://doi.org/10.1016/j.ejpb.2008.08.020
   
• Markus Thommes, Lieven Baert, Gerben van ’t Klooster, Marian Geldof, Laurent Schueller, Jan Rosier, Peter Kleinebudde
  Improved Bioavailability of Darunavir by Use of κ-Carrageenan versus Microcrystalline Cellulose as Pelletisation Aid
  (2009) European Journal of Pharmaceutics and Biopharmaceutics, 72(3), pp. 614–620
  https://doi.org/10.1016/j.ejpb.2009.03.004
   
• Markus Thommes, David R. Ely, Peter Kleinebudde
  The Water Binding Behavior of κ-Carrageenan Determined by Three Different Methods
  (2009) Pharmaceutical Development and Technology, 14(3), pp. 249–258
  https://doi.org/10.1080/10837450802572359
   
• Aleksandra Dukić-Ott, Markus Thommes, Jean Paul Remon, Peter Kleinebudde, Chris Vervaet
  Production of Pellets via Extrusion-Spheronisation without the Incorporation of Microcrystalline Cellulose: A Critical Review
  (2009) European Journal of Pharmaceutics and Biopharmaceutics, 71(1), pp. 38–46
  https://doi.org/10.1016/j.ejpb.2008.08.005
   

2008

• David R. Ely, Markus Thommes, M. Teresa Carvjal
  Analysis of the Effects of Particle Size and Densification on NIR Spectra
  (2008) Colloids and Surfaces A: Physicochemical and Engineering Aspects, 331(1-2), pp. 63–67
  https://doi.org/10.1016/j.colsurfa.2008.07.017
   
• Markus Thommes, Peter Kleinebudde
  The Behavior of Different Carrageenans in Pelletization by Extrusion/Spheronization
  (2008) Pharmaceutical Development and Technology, 13(1), pp. 27–35
  https://doi.org/10.1080/10837450701702537
   

2007

• Markus Thommes, Wolfgang Blaschek, Peter Kleinebudde
  Effect of Drying on Extruded Pellets based on κ-Carrageenan
  (2007) European Journal of Pharmaceutical Sciences, 31(2), pp. 112–118
  https://doi.org/10.1016/j.ejps.2007.02.010
   
• Markus Thommes, Peter Kleinebudde
  Properties of Pellets Manufactured by Wet Extrusion/Spheronization Process using κ-Carrageenan: Effect of Process Parameters
  (2007) AAPS PharmSciTech, 8(4), p. E95
  https://doi.org/10.1208/pt0804095
   

2006

• Markus Thommes, Peter Kleinebudde
  Use of κ-Carrageenan as Alternative Pelletisation Aid to Microcrystalline Cellulose in Extrusion/Spheronisation. I. Influence of Type and Fraction of Filler
  (2006) European Journal of Pharmaceutics and Biopharmaceutics, 63(1), pp. 59–67
  https://doi.org/10.1016/j.ejpb.2005.10.002
   
• Markus Thommes, Peter Kleinebudde
  Use of κ-Carrageenan as Alternative Pelletisation Aid to Microcrystalline Cellulose in Extrusion/Spheronisation. II. Influence of Drug and Filler Type
  (2006) European Journal of Pharmaceutics and Biopharmaceutics, 63(1), pp. 68–75
  https://doi.org/10.1016/j.ejpb.2005.10.003
   

2005

• Martin Bornhöft, Markus Thommes and Peter Kleinebudde*
  Preliminary Assessment of Carrageenan as Excipient for Extrusion/Spheronisation
  (2005) European Journal of Pharmaceutics and Biopharmaceutics, 59(1): p. 127-131.
  https://doi.org/10.1016/j.ejpb.2004.05.007