Tobias Gottschalk, M.Sc.
Contact
Address
Department of Biochemical and Chemical Engineering
Laboratory of Solids Process Engineering
Emil-Figge-Str. 68
44227 Dortmund
Contents
Abstract
Hot melt extrusion and spray drying are two commonly applied processes in several industries [1]. Within this study, the applicability in the pharmaceutical area is investigated regarding the operating conditions.
Description
TThe poor solubility of a large amount of new developed drugs is a major challenge in pharmaceutical applications. One approach to overcome this challenge is the manufacturing of so called amorphous solid dispersion (ASD), where the drug is molecularly dispersed into an amorphous carrier. Even though this strategy is known for years, only a small number of market products containing this kind of formulation is available, caused by challenges in manufacturing [1].
Within this work, the two most commonly used manufacturing techniques are compared. A special focus is on the selection of an optimized operating point, so that the manufacturing can take place as efficient as possible.
This work is a cooperation of INVITE GmbH and TU Dortmund within the frame of the consortium DDIC.
References
- Merisko-Liversidge E, Liversidge GG. Advanced drug delivery reviews 2011; 63: 427 – 440
Curriculum Vitae
since 2018 | PhD at Invite GmbH (Leverkusen) in cooperation with the Laboratory of Solids Process Engineering (TU Dortmund) within the frame of the consortium DDIC |
2016 - 2017 | M.Sc. Chemical Engineering, TU Dortmund |
2012 - 2016 | B.Sc. Chemical Engineering, TU Dortmund |
2004 - 2012 | Ricarda-Huch-Gymnasium (Hagen) |
Born | June 6th, Hagen (Germany) |