Abstract

Poorly water-soluble drugs pose a challenge for bioavailability and formulation development (Dobrowolski et al. 2019). In preliminary work a melt electrostatic precipitator was developed to produce solid crystal suspensions which increase the dissolution behavior of poorly water-soluble drugs. The process is based on the electrostatic precipitation of submicron drug particles, which are subsequently embedded in a hydrophilic carrier matrix. (Dobrowolski et al. 2019; Justen et al. 2023; Justen et al. 2024). Building on this work, the project aims to validate the technology and extend its application to various pharmaceutical dosage forms.

Description

The project focuses on two key applications: enhancing the oral bioavailability of poorly water-soluble drugs and developing dosage forms for topical and parenteral administration. Part of this work is the identification of suitable carrier materials for different applications. Furthermore, the project addresses the maximum load of submicron drug particles possible in the solid crystal suspension, and focuses on establishing a continuous solidification process.

Acknowledgement

This project is made possible by the funding of the BMBF VIP+

References

Dobrowolski, Adrian; Pieloth, Damian; Wiggers, Helmut; Thommes, Markus (2019): Electrostatic Precipitation of Submicron Particles in a Molten Carrier. In Pharmaceutics 11 (6). DOI: 10.3390/pharmaceutics11060276

Justen, Anna; Kurth, Christopher; Schaldach, Gerhard; Thommes, Markus (2023): Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation. In Chem Eng & Technol 46 (2), pp. 343–349. DOI: 10.1002/ceat.202200357

Justen, Anna; Weltersbach, Alina Faye; Schaldach, Gerhard; Thommes, Markus (2024): Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations. In Processes 12 (1), p. 100. DOI: 10.3390/pr12010100

Since 2026 PhD at the Laboratory of Solids Process Engineering, TU Dortmund

2026 Pharmacist at Westpark Apotheke, Aachen

2025 Pharmacist at Baur-Apotheke, Aachen

2025 Licensed as Pharmacist

2025 Trainee at Baur-Apotheke, Aachen

2024 Trainee at Institute of Clinical Pharmacology, University Hospital RWTH Aachen

2024 Trainee at Grünenthal, Aachen

2019 – 2024 Pharmacy Studies, Heinrich-Heine-University Düsseldorf

2010 – 2018 Konrad-Adenauer-Gymnasium, Langenfeld

Born January 5th, Langenfeld